Title : 17 beta-estradiol 2- and 4-hydroxylation catalyzed by rat hepatic cytochrome P-450: roles of individual forms, inductive effects, developmental patterns, and alterations by gonadectomy and hormone replacement.

Pub. Date : 1986 May

PMID : 3516654






2 Functional Relationships(s)
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1 It was thus demonstrated that three rat liver microsomal cytochrome P-450 forms, designated P-450UT-A, P-450PCN-E, and P-450ISF-G, each contribute to the 2- and 4-hydroxylation of 17 beta-estradiol catalyzed by hepatic microsomal preparations. Estradiol cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus
2 Two of these enzymes, P-450UT-A and P-450PCN-E, are expressed constitutively, are male-specific, and are regulated by testosterone as well as influenced by the administration of various chemicals. Testosterone cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus