Pub. Date : 2022
PMID : 35154486
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Overexpression of MFN2 alleviates sorafenib-induced cardiomyocyte necroptosis via the MAM-CaMKIIdelta pathway in vitro and in vivo. | 6-O-monoacetylmorphine | mitofusin 2 | Mus musculus |
| 2 | In an in vivo model, mice subjected to sor administration developed cardiac dysfunction, autophagy activation and necroptosis; our investigation found that global and cardiac-specific overexpression of MFN2 repressed cardiac dysfunction, and sor-induced cardiomyocyte necroptosis via repressing the MAM-CaMKIIdelta-RIP3/MLKL pathway. | 6-O-monoacetylmorphine | mitofusin 2 | Mus musculus |