Title : Inhibitory action of rat insulin and synthetic rat C-peptide on insulin secretion in the perfused rat pancreas.

Pub. Date : 1977 Sep-Dec

PMID : 349994






5 Functional Relationships(s)
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1 However, the insulin response to 16.7 mM glucose decreased in the presence of exogenous rat insulin or synthetic rat C-peptide, showing a biphasic pattern of glucose-induced insulin release. Glucose insulin 2 Rattus norvegicus
2 However, the insulin response to 16.7 mM glucose decreased in the presence of exogenous rat insulin or synthetic rat C-peptide, showing a biphasic pattern of glucose-induced insulin release. Glucose insulin 2 Rattus norvegicus
3 When rat insulin or C-peptide were added at 20 min and removed at 40 min while the isolated pancreas was exposed to a 60-min glucose infusion (16.7 mM), glucose-induced insulin secretion decreased during the infusion of rat insulin or C-peptide. Glucose insulin 2 Rattus norvegicus
4 When rat insulin or C-peptide were added at 20 min and removed at 40 min while the isolated pancreas was exposed to a 60-min glucose infusion (16.7 mM), glucose-induced insulin secretion decreased during the infusion of rat insulin or C-peptide. Glucose insulin 2 Rattus norvegicus
5 The present study clearly showed that exogenous rat insulin and synthetic rat C-peptide 1 and 2 inhibited glucose-induced insulin secretion. Glucose insulin 2 Rattus norvegicus