Pub. Date : 2022 Feb 28
PMID : 34949747
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, crude polysaccharides (GBP) were isolated from Korean ginseng berries and their immunomodulatory activities were investigated using cyclophosphamide (CY)-induced immunosuppressive BALB/c mice. | Polysaccharides | protein inhibitor of activated STAT 1 | Mus musculus |
| 2 | In this study, crude polysaccharides (GBP) were isolated from Korean ginseng berries and their immunomodulatory activities were investigated using cyclophosphamide (CY)-induced immunosuppressive BALB/c mice. | Cyclophosphamide | protein inhibitor of activated STAT 1 | Mus musculus |
| 3 | In this study, crude polysaccharides (GBP) were isolated from Korean ginseng berries and their immunomodulatory activities were investigated using cyclophosphamide (CY)-induced immunosuppressive BALB/c mice. | Cyclophosphamide | protein inhibitor of activated STAT 1 | Mus musculus |
| 4 | In CY-treated mice, oral administration of GBP (50-500 mg/kg BW) remarkably increased their spleen sizes and spleen indices and activated NK cell activities. | Cyclophosphamide | protein inhibitor of activated STAT 1 | Mus musculus |
| 5 | In addition, GBP significantly stimulated mRNA expression levels of immune-associated genes including interleukin-1beta (IL-1beta), IL-2, IL-4, IL-6, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), Toll-like receptor 4 (TLR-4), and cyclooxygenase-2 (COX-2) in CY-treated mice. | Cyclophosphamide | protein inhibitor of activated STAT 1 | Mus musculus |
| 6 | These results indicate that GBP is involved in immune effects against CY-induced immunosuppression. | Cyclophosphamide | protein inhibitor of activated STAT 1 | Mus musculus |