Title : Celastrol and Melatonin Modify SIRT1, SIRT6 and SIRT7 Gene Expression and Improve the Response of Human Granulosa-Lutein Cells to Oxidative Stress.

Pub. Date : 2021 Nov 24

PMID : 34942974






9 Functional Relationships(s)
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1 Celastrol and Melatonin Modify SIRT1, SIRT6 and SIRT7 Gene Expression and Improve the Response of Human Granulosa-Lutein Cells to Oxidative Stress. celastrol sirtuin 7 Homo sapiens
2 Celastrol and Melatonin Modify SIRT1, SIRT6 and SIRT7 Gene Expression and Improve the Response of Human Granulosa-Lutein Cells to Oxidative Stress. Melatonin sirtuin 7 Homo sapiens
3 SIRT1, SIRT6 and SIRT7 are involved in protection stress systems caused by OS, and they can be activated by antioxidants such as celastrol or melatonin. celastrol sirtuin 7 Homo sapiens
4 SIRT1, SIRT6 and SIRT7 are involved in protection stress systems caused by OS, and they can be activated by antioxidants such as celastrol or melatonin. Melatonin sirtuin 7 Homo sapiens
5 In this study, we evaluate SIRT1, SIRT6 and SIRT7 gene expression in cultured human granulosa-lutein (hGL) cells in response to OS inductors (glucose or peroxynitrite) and/or antioxidants. Glucose sirtuin 7 Homo sapiens
6 In this study, we evaluate SIRT1, SIRT6 and SIRT7 gene expression in cultured human granulosa-lutein (hGL) cells in response to OS inductors (glucose or peroxynitrite) and/or antioxidants. Peroxynitrous Acid sirtuin 7 Homo sapiens
7 In addition, melatonin induced SIRT1, SIRT6 and SIRT7 gene expression while celastrol only induced SIRT7 gene expression. Melatonin sirtuin 7 Homo sapiens
8 In addition, melatonin induced SIRT1, SIRT6 and SIRT7 gene expression while celastrol only induced SIRT7 gene expression. celastrol sirtuin 7 Homo sapiens
9 This study shows a direct effect of celastrol on SIRT7 gene expression. celastrol sirtuin 7 Homo sapiens