Pub. Date : 2021 Dec 9
PMID : 34843649
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | These assays enabled the identification of 2-(aryl)alkylthio-3,4-dihydro-4-oxoypyrimidine-5-carboxylic acids as potent MINA53 inhibitors, with selectivity over NO66 and other JmjC oxygenases. | 2-(aryl)alkylthio-3,4-dihydro-4-oxoypyrimidine-5-carboxylic acids | ribosomal oxygenase 2 | Homo sapiens |
| 2 | Crystallographic studies with the JmjC demethylase KDM5B revealed active site binding but without direct metal chelation; however, molecular modeling investigations indicated that the inhibitors bind to MINA53 by directly interacting with the iron cofactor. | Iron | ribosomal oxygenase 2 | Homo sapiens |