Pub. Date : 2021 Oct 23
PMID : 34687232
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Next-Generation Sequencing and Genotype Association Studies Reveal the Association of HLA-DRB3*02:02 With Delayed Hypersensitivity to Penicillins. | Penicillins | major histocompatibility complex, class II, DR beta 3 | Homo sapiens |
| 2 | The haplotype (ACAA) from rs9268835, rs6923504, rs6903608, and rs9268838 genetic variants of the HLA-DRB3 genomic region was significantly associated with an increased risk of delayed hypersensitivity to penicillins (OR, 1.7; 95% CI: 1.06-1.92; P=0.001), but not immediate hypersensitivity. | Penicillins | major histocompatibility complex, class II, DR beta 3 | Homo sapiens |
| 3 | CONCLUSION: We showed that the HLA-DRB3 locus is strongly associated with an increased risk of delayed penicillin hypersensitivity, at least in Southwestern Europe. | Penicillins | major histocompatibility complex, class II, DR beta 3 | Homo sapiens |
| 4 | The determination of HLA-DRB3*02:02 alleles in the risk management of severe delayed hypersensitivity to penicillins should be evaluated further in larger population samples of different origins. | Penicillins | major histocompatibility complex, class II, DR beta 3 | Homo sapiens |