PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34687232-0 2021 Next-Generation Sequencing and Genotype Association Studies Reveal the Association of HLA-DRB3*02:02 With Delayed Hypersensitivity to Penicillins. Penicillins 134-145 major histocompatibility complex, class II, DR beta 3 Homo sapiens 86-94 34687232-8 2021 The haplotype (ACAA) from rs9268835, rs6923504, rs6903608, and rs9268838 genetic variants of the HLA-DRB3 genomic region was significantly associated with an increased risk of delayed hypersensitivity to penicillins (OR, 1.7; 95% CI: 1.06-1.92; P=0.001), but not immediate hypersensitivity. Penicillins 204-215 acetyl-CoA acyltransferase 1 Homo sapiens 15-19 34687232-8 2021 The haplotype (ACAA) from rs9268835, rs6923504, rs6903608, and rs9268838 genetic variants of the HLA-DRB3 genomic region was significantly associated with an increased risk of delayed hypersensitivity to penicillins (OR, 1.7; 95% CI: 1.06-1.92; P=0.001), but not immediate hypersensitivity. Penicillins 204-215 major histocompatibility complex, class II, DR beta 3 Homo sapiens 97-105 34687232-9 2021 CONCLUSION: We showed that the HLA-DRB3 locus is strongly associated with an increased risk of delayed penicillin hypersensitivity, at least in Southwestern Europe. Penicillins 103-113 major histocompatibility complex, class II, DR beta 3 Homo sapiens 31-39 34687232-10 2021 The determination of HLA-DRB3*02:02 alleles in the risk management of severe delayed hypersensitivity to penicillins should be evaluated further in larger population samples of different origins. Penicillins 105-116 major histocompatibility complex, class II, DR beta 3 Homo sapiens 21-29