Pub. Date : 2021
PMID : 34539418
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | alpha-Mangostin Induces Apoptosis and Inhibits Metastasis of Breast Cancer Cells via Regulating RXRalpha-AKT Signaling Pathway. | mangostin | retinoid X receptor alpha | Homo sapiens |
| 2 | Then the effect of alpha-Mangostin on the transcriptional activity of RXRalpha was tested by dual-luciferase reporter gene assay. | mangostin | retinoid X receptor alpha | Homo sapiens |
| 3 | alpha-Mangostin regulates the downstream effectors of the PI3K/AKT signaling pathway by degrading RXRalpha/tRXRalpha. | mangostin | retinoid X receptor alpha | Homo sapiens |
| 4 | alpha-Mangostin induces apoptosis, suppresses the migration and invasion of breast cancer cells through the PI3K/AKT signaling pathway by targeting RXRalpha, and cyclin D1 has involved in this process. | mangostin | retinoid X receptor alpha | Homo sapiens |