Title : Exosomal Micro-RNA-96 Derived From Bone Marrow Mesenchymal Stem Cells Inhibits Doxorubicin-Induced Myocardial Toxicity by Inhibiting the Rac1/Nuclear Factor-κB Signaling Pathway.

Pub. Date : 2021 Sep 7

PMID : 34459233






3 Functional Relationships(s)
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1 Exosomal Micro-RNA-96 Derived From Bone Marrow Mesenchymal Stem Cells Inhibits Doxorubicin-Induced Myocardial Toxicity by Inhibiting the Rac1/Nuclear Factor-kappaB Signaling Pathway. Doxorubicin Rac family small GTPase 1 Rattus norvegicus
2 miR-96 was downregulated, Rac1 was upregulated and the nuclear factor-kappaB signaling pathway was activated in doxorubicin-induced cell and animal models. Doxorubicin Rac family small GTPase 1 Rattus norvegicus
3 Rac1 inhibition could downregulate the expression of the nuclear factor-kappaB signaling and further reverse the promotion of miR-96 knockdown on doxorubicin-induced myocardial toxicity. Doxorubicin Rac family small GTPase 1 Rattus norvegicus