Pub. Date : 2021 Dec
PMID : 34332177
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bortezomib exerts cytotoxic action in MCL cells via stabilization of the pro-apoptotic BCL-2 family protein NOXA. | Bortezomib | phorbol-12-myristate-13-acetate-induced protein 1 | Mus musculus |
| 2 | Here we show that autophagic degradation of NOXA is a mechanism of bortezomib resistance in MCL cells in a tumor microenvironment. | Bortezomib | phorbol-12-myristate-13-acetate-induced protein 1 | Mus musculus |
| 3 | Co-culture of MCL cells with stromal cells enhanced bortezomib-induced ubiquitination and subsequent binding of NOXA to the p62 adaptor, which escorted NOXA to the lysosome for autophagic degradation. | Bortezomib | phorbol-12-myristate-13-acetate-induced protein 1 | Mus musculus |
| 4 | Co-culture of MCL cells with stromal cells enhanced bortezomib-induced ubiquitination and subsequent binding of NOXA to the p62 adaptor, which escorted NOXA to the lysosome for autophagic degradation. | Bortezomib | phorbol-12-myristate-13-acetate-induced protein 1 | Mus musculus |