Pub. Date : 2021 Oct
PMID : 34312304
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Icotinib induces mechanism-based inactivation of r hCYP3A4/5 possibly via heme destruction by ketene intermediate. | ketene | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | CYP3A4 dominated the metabolic activation of ICT to the ketene intermediate. | ketene | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | In conclusion, this study demonstrated that ICT was a mechanism-based inactivator of rhCYP3A4/5, and heme destruction by the ketene metabolite may be responsible for the observed CYP3A inactivation. | ketene | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |