Title : Actin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemia.

Pub. Date : 2021 Jun 25

PMID : 34172833






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Midostaurin resistance can be overcome by a combination of midostaruin, the BCL-2 inhibitor venetoclax and the RAC1 inhibitor Eht1864 in midostaurin-resistant AML cell lines and primary samples, providing the first evidence of a potential new treatment approach to eradicate FLT3-ITD + AML. EHT 1864 Rac family small GTPase 1 Homo sapiens
2 Midostaurin resistance can be overcome by a combination of midostaruin, the BCL-2 inhibitor venetoclax and the RAC1 inhibitor Eht1864 in midostaurin-resistant AML cell lines and primary samples, providing the first evidence of a potential new treatment approach to eradicate FLT3-ITD + AML. EHT 1864 fms related receptor tyrosine kinase 3 Homo sapiens