Pub. Date : 1988 Aug 15
PMID : 3415241
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | P-450 UT-2 (P-450h) had high aminopyrine N-demethylation and hydroxylation activities, but P-450 F-2 (P-450i) had low N-demethylation activity and no hydroxylation activities, but P-450 F-2 (P-450i) had low N-demethylation activity and no hydroxylation activity. | Aminopyrine | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 2 | P-450 UT-2 (P-450h) had high aminopyrine N-demethylation and hydroxylation activities, but P-450 F-2 (P-450i) had low N-demethylation activity and no hydroxylation activities, but P-450 F-2 (P-450i) had low N-demethylation activity and no hydroxylation activity. | Aminopyrine | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 3 | P-450 UT-2 (P-450h) had high aminopyrine N-demethylation and hydroxylation activities, but P-450 F-2 (P-450i) had low N-demethylation activity and no hydroxylation activities, but P-450 F-2 (P-450i) had low N-demethylation activity and no hydroxylation activity. | Nitrogen | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 4 | P-450 UT-2 (P-450h) had high aminopyrine N-demethylation and hydroxylation activities, but P-450 F-2 (P-450i) had low N-demethylation activity and no hydroxylation activities, but P-450 F-2 (P-450i) had low N-demethylation activity and no hydroxylation activity. | Nitrogen | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 5 | Addition of cytochrome b5 to the reconstituted system enhanced the aminopyrine hydroxylation activities of P-450s UT-1, UT-2, PB-2, and PB-5. | Aminopyrine | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 6 | The kinetics of the four major cytochrome P-450s (P-450 UT-2, UT-4, PB-4, and MC-5) for aminopyrine N-demethylation and hydroxylation activities were studied. | Aminopyrine | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 7 | P-450s PB-4 and UT-2 had similar Km values (0.50 and 0.62 mM, respectively) in aminopyrine N-demethylation activity. | Aminopyrine | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |