Title : A novel leukemic route of mutant NPM1 through nuclear import of the overexpressed long noncoding RNA LONA.

Pub. Date : 2021 Oct

PMID : 34131282






1 Functional Relationships(s)
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1 In vivo, LONA overexpression acts as an oncogenic lncRNA reducing the survival of mice transplanted with AML cells and rendering AML tumors more resistant to AraC chemotherapy.These data indicate that mutation-dependent nuclear export of NPM1 leads to nuclear retention and consequent oncogenic functions of the overexpressed lncRNA LONA, thus uncovering a novel NPM1 mutation-dependent pathway in AML pathogenesis. Cytarabine nucleophosmin 1 Mus musculus