Title : EPC-Derived Exosomal miR-1246 and miR-1290 Regulate Phenotypic Changes of Fibroblasts to Endothelial Cells to Exert Protective Effects on Myocardial Infarction by Targeting ELF5 and SP1.

Pub. Date : 2021

PMID : 34055778






1 Functional Relationships(s)
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1 Furthermore, in vivo animal studies showed that exosomes from EPCs with miR-1246 or miR-1290 overexpression attenuated the MI-induced cardiac injury in the rats and caused an increase in ELF5, SP1, and CD31 expression, respectively, but suppressed alpha-SMA expression in the cardiac tissues. mir-1290 platelet and endothelial cell adhesion molecule 1 Rattus norvegicus