Pub. Date : 2021 Jul
PMID : 34030962
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A natural compound harmine decreases melanin synthesis through regulation of the DYRK1A/NFATC3 pathway. | Harmine | nuclear factor of activated T cells 3 | Homo sapiens |
| 2 | A natural compound harmine decreases melanin synthesis through regulation of the DYRK1A/NFATC3 pathway. | Melanins | nuclear factor of activated T cells 3 | Homo sapiens |
| 3 | Further studies revealed that nuclear translocation of NFATC3, a potential DYRK1A substrate, was induced via the harmine/DYRK1A pathway and that NFATC3 knockdown increased melanin synthesis and tyrosinase expression. | Melanins | nuclear factor of activated T cells 3 | Homo sapiens |
| 4 | Further studies revealed that nuclear translocation of NFATC3, a potential DYRK1A substrate, was induced via the harmine/DYRK1A pathway and that NFATC3 knockdown increased melanin synthesis and tyrosinase expression. | Melanins | nuclear factor of activated T cells 3 | Homo sapiens |
| 5 | Suppression of melanin synthesis and tyrosinase expression via the harmine/DYRK1A pathway was significantly attenuated by NFATC3 knockdown. | Melanins | nuclear factor of activated T cells 3 | Homo sapiens |
| 6 | Furthermore, harmine also decreased melanin synthesis and tyrosinase expression through regulation of NFATC3 in human primary melanocytes. | Harmine | nuclear factor of activated T cells 3 | Homo sapiens |
| 7 | CONCLUSION: Our results indicate that harmine decreases melanin synthesis through regulation of the DYRK1A/NFATC3 pathway and suggest that the DYRK1A/NFATC3 pathway may be a potential target for the development of depigmenting agents. | Harmine | nuclear factor of activated T cells 3 | Homo sapiens |
| 8 | CONCLUSION: Our results indicate that harmine decreases melanin synthesis through regulation of the DYRK1A/NFATC3 pathway and suggest that the DYRK1A/NFATC3 pathway may be a potential target for the development of depigmenting agents. | Harmine | nuclear factor of activated T cells 3 | Homo sapiens |
| 9 | CONCLUSION: Our results indicate that harmine decreases melanin synthesis through regulation of the DYRK1A/NFATC3 pathway and suggest that the DYRK1A/NFATC3 pathway may be a potential target for the development of depigmenting agents. | Melanins | nuclear factor of activated T cells 3 | Homo sapiens |
| 10 | CONCLUSION: Our results indicate that harmine decreases melanin synthesis through regulation of the DYRK1A/NFATC3 pathway and suggest that the DYRK1A/NFATC3 pathway may be a potential target for the development of depigmenting agents. | Melanins | nuclear factor of activated T cells 3 | Homo sapiens |