Title : Phoenixin-20 Prevents ox-LDL-Induced Attachment of Monocytes to Human Aortic Endothelial Cells (HAECs): A Protective Implication in Atherosclerosis.

Pub. Date : 2021 Mar 17

PMID : 33683115






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 G-protein receptor-coupled 173 (GPR173) is the putative receptor of Phoenixin-20. phoenixin G protein-coupled receptor 173 Homo sapiens
2 G-protein receptor-coupled 173 (GPR173) is the putative receptor of Phoenixin-20. phoenixin G protein-coupled receptor 173 Homo sapiens
3 However, the agonism of GPR173 using Phoenixin-20 significantly ameliorates all of these harmful effects from ox-LDL by suppressing the NF-kappaB pathway. phoenixin-20 G protein-coupled receptor 173 Homo sapiens
4 Furthermore, we show that agonism of GPR173 by Phoenixin-20 prevents the attachment of monocytes THP-1 to endothelial cells, which is an important therapeutic approach to preventing atherogenesis. phoenixin-20 G protein-coupled receptor 173 Homo sapiens
5 In conclusion, our study demonstrates that GPR173 agonism by Phoenixin-20 plays a protective role against ox-LDL-induced endothelial dysfunction, implying that Phoenixin-20 may have therapeutic implications in atherosclerosis. phoenixin-20 G protein-coupled receptor 173 Homo sapiens
6 In conclusion, our study demonstrates that GPR173 agonism by Phoenixin-20 plays a protective role against ox-LDL-induced endothelial dysfunction, implying that Phoenixin-20 may have therapeutic implications in atherosclerosis. phoenixin-20 G protein-coupled receptor 173 Homo sapiens