Title : Monocyte Chemotactic Protein 1-Induced Protein 1 Is Highly Expressed in Inflammatory Bowel Disease and Negatively Regulates Neutrophil Activities.

Pub. Date : 2020

PMID : 33488293






3 Functional Relationships(s)
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Protein Name
Organism
1 Interestingly, MG-132, a proteasome inhibitor reducing the degradation of MCPIP-1, further facilitated neutrophils to express MCPIP-1 in vitro. benzyloxycarbonylleucyl-leucyl-leucine aldehyde zinc finger CCCH-type containing 12A Homo sapiens
2 Interestingly, MG-132, a proteasome inhibitor reducing the degradation of MCPIP-1, further facilitated neutrophils to express MCPIP-1 in vitro. benzyloxycarbonylleucyl-leucyl-leucine aldehyde zinc finger CCCH-type containing 12A Homo sapiens
3 Importantly, MCPIP-1 markedly downregulated the production of ROS, MPO, and proinflammatory cytokines (e.g., interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, interleukin-8, and interferon-gamma) and suppressed the migration of IBD neutrophils. ros zinc finger CCCH-type containing 12A Homo sapiens