PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33488293-4 2020 Interestingly, MG-132, a proteasome inhibitor reducing the degradation of MCPIP-1, further facilitated neutrophils to express MCPIP-1 in vitro. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 15-21 zinc finger CCCH-type containing 12A Homo sapiens 74-81 33488293-4 2020 Interestingly, MG-132, a proteasome inhibitor reducing the degradation of MCPIP-1, further facilitated neutrophils to express MCPIP-1 in vitro. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 15-21 zinc finger CCCH-type containing 12A Homo sapiens 126-133 33488293-5 2020 Importantly, MCPIP-1 markedly downregulated the production of ROS, MPO, and proinflammatory cytokines (e.g., interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, interleukin-8, and interferon-gamma) and suppressed the migration of IBD neutrophils. ros 62-65 zinc finger CCCH-type containing 12A Homo sapiens 13-20 33488293-6 2020 Consistently, the same functional changes were observed in neutrophils from mice with myeloid-targeted overexpression of MCPIP-1 as MG-132 did. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 132-138 zinc finger CCCH type containing 12A Mus musculus 121-128 33488293-7 2020 Altogether, these findings suggest that MCPIP-1 plays a negative role in regulating neutrophil activities through suppressing the production of ROS, MPO, and proinflammatory cytokines and inhibiting the migration. ros 144-147 zinc finger CCCH type containing 12A Mus musculus 40-47 33488293-8 2020 MG-132 may partially modulate the function of neutrophils via the induction of MCPIP-1. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 0-6 zinc finger CCCH type containing 12A Mus musculus 79-86