Pub. Date : 2021 Jan 22
PMID : 33483477
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have previously identified hypotaurine as one of the top-ranked metabolites for differentiating low- and high-grade tumors, and that there is also a strong association between the levels of intratumoral hypotaurine and expression of its biosynthetic enzyme, cysteamine (2-aminoethanethiol) dioxygenase (ADO). | hypotaurine | 2-aminoethanethiol (cysteamine) dioxygenase | Mus musculus |
| 2 | Using transcription profiling, we further uncovered that the ADO/hypotaurine axis targets CCL20 secretion through activating the NF-kappaB pathway to drive the self-renewal and maintenance of glioma "cancer stem cells" or glioma cancer stem-like cells. | hypotaurine | 2-aminoethanethiol (cysteamine) dioxygenase | Mus musculus |
| 3 | Using transcription profiling, we further uncovered that the ADO/hypotaurine axis targets CCL20 secretion through activating the NF-kappaB pathway to drive the self-renewal and maintenance of glioma "cancer stem cells" or glioma cancer stem-like cells. | hypotaurine | chemokine (C-C motif) ligand 20 | Mus musculus |
| 4 | Using transcription profiling, we further uncovered that the ADO/hypotaurine axis targets CCL20 secretion through activating the NF-kappaB pathway to drive the self-renewal and maintenance of glioma "cancer stem cells" or glioma cancer stem-like cells. | hypotaurine | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 5 | Conversely, abrogating the ADO/hypotaurine axis using CRISPR/Cas9-mediated gene editing limited glioblastoma cell proliferation and self-renewal in vitro and tumor growth in vivo in an orthotopical mouse model, indicating that this metabolic pathway is a potential key therapeutic target. | hypotaurine | 2-aminoethanethiol (cysteamine) dioxygenase | Mus musculus |