Title : Effects of miR-7 on Hcy-induced rat cerebral arterial vascular smooth muscle cell proliferation, migration and inflammatory factor expression by targeting MMP-14 to regulate TLR4/NF-κB signaling pathway.

Pub. Date : 2020 Oct 31

PMID : 33287916






8 Functional Relationships(s)
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1 Effects of miR-7 on Hcy-induced rat cerebral arterial vascular smooth muscle cell proliferation, migration and inflammatory factor expression by targeting MMP-14 to regulate TLR4/NF-kappaB signaling pathway. Homocysteine matrix metallopeptidase 14 Rattus norvegicus
2 The current research aimed to investigate the effect of miR-7 targeting matrix metalloproteinase 14 (MMP-14) on homocysteine (Hcy)-induced rat cerebral artery vascular smooth muscle cells (VSMCs) proliferation, migration and inflammatory factor expression and its possible mechanism. Homocysteine matrix metallopeptidase 14 Rattus norvegicus
3 The current research aimed to investigate the effect of miR-7 targeting matrix metalloproteinase 14 (MMP-14) on homocysteine (Hcy)-induced rat cerebral artery vascular smooth muscle cells (VSMCs) proliferation, migration and inflammatory factor expression and its possible mechanism. Homocysteine matrix metallopeptidase 14 Rattus norvegicus
4 The current research aimed to investigate the effect of miR-7 targeting matrix metalloproteinase 14 (MMP-14) on homocysteine (Hcy)-induced rat cerebral artery vascular smooth muscle cells (VSMCs) proliferation, migration and inflammatory factor expression and its possible mechanism. Homocysteine matrix metallopeptidase 14 Rattus norvegicus
5 The current research aimed to investigate the effect of miR-7 targeting matrix metalloproteinase 14 (MMP-14) on homocysteine (Hcy)-induced rat cerebral artery vascular smooth muscle cells (VSMCs) proliferation, migration and inflammatory factor expression and its possible mechanism. Homocysteine matrix metallopeptidase 14 Rattus norvegicus
6 The expression of miR-7 and MMP-14 in Hcy-induced VSMCs were detected by real-time fluorescent quantitative PCR (RT-qPCR) and Western blot. Homocysteine matrix metallopeptidase 14 Rattus norvegicus
7 Overexpression of MMP-14 and/or activation of the TLR4/NF-kappaB signaling pathway could reverse the effect of miR-7 overexpression on the proliferation, migration and IL-6 and TNF-alpha expression of Hcy-induced VSMCs (P<0.05). Homocysteine matrix metallopeptidase 14 Rattus norvegicus
8 It is concluded that miR-7 can inhibit Hcy-induced rat cerebral artery VSMCs proliferation, migration, and inflammatory factor expression by targeting the regulation of MMP-14 expression and inhibiting the activation of the TLR4/NF-kappaB signaling pathway. Homocysteine matrix metallopeptidase 14 Rattus norvegicus