Title : Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors.

Pub. Date : 2021 Jan 1

PMID : 33221064






2 Functional Relationships(s)
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Protein Name
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1 Leucyl-tRNA synthetase (LeuRS) catalyzes the attachment of l-leucine to tRNALeu, which plays an essential role in protein translation and is considered an attractive antimicrobial drug target. Leucine leucyl-tRNA synthetase 2, mitochondrial Homo sapiens
2 In the present work, benzhydrol-oxaborole hybrid compounds were designed and synthesized as inhibitors of S. pneumoniae LeuRS. benzhydrol-oxaborole leucyl-tRNA synthetase 2, mitochondrial Homo sapiens