PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33189448-0	2021	Bisphenol AF induces apoptosis via estrogen receptor beta (ERbeta) and ROS-ASK1-JNK MAPK pathway in human granulosa cell line KGN.	bis(4-hydroxyphenyl)sulfone	0-9	estrogen receptor 1	Homo sapiens	35-57	
33189448-0	2021	Bisphenol AF induces apoptosis via estrogen receptor beta (ERbeta) and ROS-ASK1-JNK MAPK pathway in human granulosa cell line KGN.	bis(4-hydroxyphenyl)sulfone	0-9	estrogen receptor 1	Homo sapiens	59-65	
33189448-0	2021	Bisphenol AF induces apoptosis via estrogen receptor beta (ERbeta) and ROS-ASK1-JNK MAPK pathway in human granulosa cell line KGN.	bis(4-hydroxyphenyl)sulfone	0-9	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	75-79	
33189448-5	2021	Meanwhile, BPAF exposure significantly promoted the expression of pro-apoptotic proteins, including Bax, Bid and Bak, while the expression of anti-apoptotic proteins, such as Bcl-2, Bcl-xL and Mcl-1, decreased significantly.	4,4'-hexafluorisopropylidene diphenol	11-15	BCL2 associated X, apoptosis regulator	Homo sapiens	100-103	
33189448-5	2021	Meanwhile, BPAF exposure significantly promoted the expression of pro-apoptotic proteins, including Bax, Bid and Bak, while the expression of anti-apoptotic proteins, such as Bcl-2, Bcl-xL and Mcl-1, decreased significantly.	4,4'-hexafluorisopropylidene diphenol	11-15	BH3 interacting domain death agonist	Homo sapiens	105-108	
33189448-5	2021	Meanwhile, BPAF exposure significantly promoted the expression of pro-apoptotic proteins, including Bax, Bid and Bak, while the expression of anti-apoptotic proteins, such as Bcl-2, Bcl-xL and Mcl-1, decreased significantly.	4,4'-hexafluorisopropylidene diphenol	11-15	BCL2 antagonist/killer 1	Homo sapiens	113-116	
33189448-5	2021	Meanwhile, BPAF exposure significantly promoted the expression of pro-apoptotic proteins, including Bax, Bid and Bak, while the expression of anti-apoptotic proteins, such as Bcl-2, Bcl-xL and Mcl-1, decreased significantly.	4,4'-hexafluorisopropylidene diphenol	11-15	BCL2 apoptosis regulator	Homo sapiens	175-180	
33189448-5	2021	Meanwhile, BPAF exposure significantly promoted the expression of pro-apoptotic proteins, including Bax, Bid and Bak, while the expression of anti-apoptotic proteins, such as Bcl-2, Bcl-xL and Mcl-1, decreased significantly.	4,4'-hexafluorisopropylidene diphenol	11-15	BCL2 like 1	Homo sapiens	182-188	
33189448-5	2021	Meanwhile, BPAF exposure significantly promoted the expression of pro-apoptotic proteins, including Bax, Bid and Bak, while the expression of anti-apoptotic proteins, such as Bcl-2, Bcl-xL and Mcl-1, decreased significantly.	4,4'-hexafluorisopropylidene diphenol	11-15	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	193-198	
33189448-7	2021	After blocking the corresponding pathway, it was found that ROS mediates ASK1 and JNK activation.	ros	60-63	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	73-77	
33189448-7	2021	After blocking the corresponding pathway, it was found that ROS mediates ASK1 and JNK activation.	ros	60-63	mitogen-activated protein kinase 8	Homo sapiens	82-85	
33189448-8	2021	Furthermore, the role of Ca2+ overload and estrogen receptor beta (ERbeta) in BPAF-induced KGN cell apoptosis was also confirmed by using inhibitors.	4,4'-hexafluorisopropylidene diphenol	78-82	estrogen receptor 1	Homo sapiens	43-65	
33189448-8	2021	Furthermore, the role of Ca2+ overload and estrogen receptor beta (ERbeta) in BPAF-induced KGN cell apoptosis was also confirmed by using inhibitors.	4,4'-hexafluorisopropylidene diphenol	78-82	estrogen receptor 1	Homo sapiens	67-73	
33189448-9	2021	These results suggest that BPAF has potential reproductive toxicity for females, and ROS-ASK1-JNK axis may play a key role in BPAF-induced ovarian dysfunction.	4,4'-hexafluorisopropylidene diphenol	126-130	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	89-93	
33189448-9	2021	These results suggest that BPAF has potential reproductive toxicity for females, and ROS-ASK1-JNK axis may play a key role in BPAF-induced ovarian dysfunction.	4,4'-hexafluorisopropylidene diphenol	126-130	mitogen-activated protein kinase 8	Homo sapiens	94-97	
33189448-10	2021	In addition, Ca2+ overload and ERbeta pathway activation may also be an important mechanism of reproductive toxicity of BPAF.	4,4'-hexafluorisopropylidene diphenol	120-124	estrogen receptor 1	Homo sapiens	31-37