Pub. Date : 2021 Jan 1
PMID : 33130075
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ortho-silicic acid enhances osteogenesis of osteoblasts through the upregulation of miR-130b which directly targets PTEN. | Orthosilicic acid | microRNA 130b | Homo sapiens |
| 2 | This study investigated the role of miR-130b in promoting osteogenesis induced by ortho-silicic acid. | Orthosilicic acid | microRNA 130b | Homo sapiens |
| 3 | Furthermore, the expression of miR-130b increased under application of ortho-silicic acid. | Orthosilicic acid | microRNA 130b | Homo sapiens |
| 4 | In vitro, experiments demonstrated miR-130b overexpression or inhibition significantly promoted or suppressed osteogenic differentiation of osteoblasts under application of ortho-silicic acid, respectively. | Orthosilicic acid | microRNA 130b | Homo sapiens |
| 5 | Mechanistically, we identified phosphatase and tensin homologue deleted on human chromosome 10 (PTEN) as the direct target of miR-130b during osteogenesis induced by ortho-silicic acid. | Orthosilicic acid | microRNA 130b | Homo sapiens |
| 6 | SIGNIFICANCE: In conclusion, our findings reveal that ortho-silicic acid promotes the osteogenesis of osteoblasts mediated by the miR-130b/PTEN signaling axis, which identifies a new target to prevent and treat osteoporosis. | Orthosilicic acid | microRNA 130b | Homo sapiens |