PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33130075-0 2021 Ortho-silicic acid enhances osteogenesis of osteoblasts through the upregulation of miR-130b which directly targets PTEN. Orthosilicic acid 0-18 microRNA 130b Homo sapiens 84-92 33130075-0 2021 Ortho-silicic acid enhances osteogenesis of osteoblasts through the upregulation of miR-130b which directly targets PTEN. Orthosilicic acid 0-18 phosphatase and tensin homolog Homo sapiens 116-120 33130075-5 2021 This study investigated the role of miR-130b in promoting osteogenesis induced by ortho-silicic acid. Orthosilicic acid 82-100 microRNA 130b Homo sapiens 36-44 33130075-7 2021 Furthermore, the expression of miR-130b increased under application of ortho-silicic acid. Orthosilicic acid 71-89 microRNA 130b Homo sapiens 31-39 33130075-8 2021 In vitro, experiments demonstrated miR-130b overexpression or inhibition significantly promoted or suppressed osteogenic differentiation of osteoblasts under application of ortho-silicic acid, respectively. Orthosilicic acid 173-191 microRNA 130b Homo sapiens 35-43 33130075-9 2021 Consistently, downregulation of miR-130b in ovariectomy (OVX) rats dropped off the beneficial effect of ortho-silicic acid against bone loss. Orthosilicic acid 104-122 microRNA 130b Rattus norvegicus 32-40 33130075-10 2021 Mechanistically, we identified phosphatase and tensin homologue deleted on human chromosome 10 (PTEN) as the direct target of miR-130b during osteogenesis induced by ortho-silicic acid. Orthosilicic acid 166-184 phosphatase and tensin homolog Homo sapiens 96-100 33130075-10 2021 Mechanistically, we identified phosphatase and tensin homologue deleted on human chromosome 10 (PTEN) as the direct target of miR-130b during osteogenesis induced by ortho-silicic acid. Orthosilicic acid 166-184 microRNA 130b Homo sapiens 126-134 33130075-11 2021 SIGNIFICANCE: In conclusion, our findings reveal that ortho-silicic acid promotes the osteogenesis of osteoblasts mediated by the miR-130b/PTEN signaling axis, which identifies a new target to prevent and treat osteoporosis. Orthosilicic acid 54-72 microRNA 130b Homo sapiens 130-138 33130075-11 2021 SIGNIFICANCE: In conclusion, our findings reveal that ortho-silicic acid promotes the osteogenesis of osteoblasts mediated by the miR-130b/PTEN signaling axis, which identifies a new target to prevent and treat osteoporosis. Orthosilicic acid 54-72 phosphatase and tensin homolog Homo sapiens 139-143