Title : Role of microRNA-15a-5p/TNFAIP3-interacting protein 2 axis in acute lung injury induced by traumatic hemorrhagic shock.

Pub. Date : 2020 Nov

PMID : 32934667






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 TNIP2 represents a direct target of miR-15a-5p, and it was downregulated in both patients with THS and the THS rat model. THYMIDINE-5'-(DITHIO)PHOSPHATE TNFAIP3 interacting protein 2 Homo sapiens
2 TNIP2 represents a direct target of miR-15a-5p, and it was downregulated in both patients with THS and the THS rat model. THYMIDINE-5'-(DITHIO)PHOSPHATE TNFAIP3 interacting protein 2 Homo sapiens
3 Moreover, it was demonstrated that all the effects of miR-15a-5p on THS rats were ablated following TNIP2 silencing. THYMIDINE-5'-(DITHIO)PHOSPHATE TNFAIP3 interacting protein 2 Rattus norvegicus
4 Taken together, the data of the current study indicate that miR-15a-5p downregulation serves a protective role in THS-induced acute lung injury via directly targeting TNIP2. THYMIDINE-5'-(DITHIO)PHOSPHATE TNFAIP3 interacting protein 2 Rattus norvegicus