Pub. Date : 2020 Sep 10
PMID : 32828280
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rosiglitazone binds to RXRalpha to induce RXRalpha tetramerization and NB4 cell differentiation. | Rosiglitazone | retinoid X receptor alpha | Homo sapiens |
| 2 | Rosiglitazone binds to RXRalpha to induce RXRalpha tetramerization and NB4 cell differentiation. | Rosiglitazone | retinoid X receptor alpha | Homo sapiens |
| 3 | In this study, we defined that rosiglitazone was also a ligand of retinoid X receptor alpha (RXRalpha) and displayed RXRalpha-dependent activities. | Rosiglitazone | retinoid X receptor alpha | Homo sapiens |
| 4 | In this study, we defined that rosiglitazone was also a ligand of retinoid X receptor alpha (RXRalpha) and displayed RXRalpha-dependent activities. | Rosiglitazone | retinoid X receptor alpha | Homo sapiens |
| 5 | In this study, we defined that rosiglitazone was also a ligand of retinoid X receptor alpha (RXRalpha) and displayed RXRalpha-dependent activities. | Rosiglitazone | retinoid X receptor alpha | Homo sapiens |
| 6 | We found that rosiglitazone directly bound to the ligand binding domain (LBD) of RXRalpha and induced RXRalpha/LBD tetramerization. | Rosiglitazone | retinoid X receptor alpha | Homo sapiens |
| 7 | We found that rosiglitazone directly bound to the ligand binding domain (LBD) of RXRalpha and induced RXRalpha/LBD tetramerization. | Rosiglitazone | retinoid X receptor alpha | Homo sapiens |
| 8 | Rosiglitazone inhibited the agonist-induced transcriptional activity of RXRalpha homodimers and heterodimers likely through inhibiting RXRalpha homo- and hetero-dimerization. | Rosiglitazone | retinoid X receptor alpha | Homo sapiens |
| 9 | Rosiglitazone inhibited the agonist-induced transcriptional activity of RXRalpha homodimers and heterodimers likely through inhibiting RXRalpha homo- and hetero-dimerization. | Rosiglitazone | retinoid X receptor alpha | Homo sapiens |
| 10 | In acute promyelocytic leukemia (APL) NB4 cells, rosiglitazone inhibited cell proliferation and induced cell differentiation, resulting from inhibiting RXRalpha/PML-RARalpha complex formation and down-regulating PML-RARalpha. | Rosiglitazone | retinoid X receptor alpha | Homo sapiens |
| 11 | Together, our study identified RXRalpha as a novel target of rosiglitazone and RXRalpha mediating the anti-APL activity of rosiglitazone. | Rosiglitazone | retinoid X receptor alpha | Homo sapiens |
| 12 | Together, our study identified RXRalpha as a novel target of rosiglitazone and RXRalpha mediating the anti-APL activity of rosiglitazone. | Rosiglitazone | retinoid X receptor alpha | Homo sapiens |
| 13 | Together, our study identified RXRalpha as a novel target of rosiglitazone and RXRalpha mediating the anti-APL activity of rosiglitazone. | Rosiglitazone | retinoid X receptor alpha | Homo sapiens |