PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32828280-0 2020 Rosiglitazone binds to RXRalpha to induce RXRalpha tetramerization and NB4 cell differentiation. Rosiglitazone 0-13 retinoid X receptor alpha Homo sapiens 23-31 32828280-0 2020 Rosiglitazone binds to RXRalpha to induce RXRalpha tetramerization and NB4 cell differentiation. Rosiglitazone 0-13 retinoid X receptor alpha Homo sapiens 42-50 32828280-1 2020 Rosiglitazone is a ligand of peroxisome proliferation-activated receptor gamma (PPARgamma). Rosiglitazone 0-13 peroxisome proliferator activated receptor gamma Homo sapiens 29-78 32828280-1 2020 Rosiglitazone is a ligand of peroxisome proliferation-activated receptor gamma (PPARgamma). Rosiglitazone 0-13 peroxisome proliferator activated receptor gamma Homo sapiens 80-89 32828280-3 2020 In this study, we defined that rosiglitazone was also a ligand of retinoid X receptor alpha (RXRalpha) and displayed RXRalpha-dependent activities. Rosiglitazone 31-44 retinoid X receptor alpha Homo sapiens 66-91 32828280-3 2020 In this study, we defined that rosiglitazone was also a ligand of retinoid X receptor alpha (RXRalpha) and displayed RXRalpha-dependent activities. Rosiglitazone 31-44 retinoid X receptor alpha Homo sapiens 93-101 32828280-3 2020 In this study, we defined that rosiglitazone was also a ligand of retinoid X receptor alpha (RXRalpha) and displayed RXRalpha-dependent activities. Rosiglitazone 31-44 retinoid X receptor alpha Homo sapiens 117-125 32828280-4 2020 We found that rosiglitazone directly bound to the ligand binding domain (LBD) of RXRalpha and induced RXRalpha/LBD tetramerization. Rosiglitazone 14-27 retinoid X receptor alpha Homo sapiens 81-89 32828280-4 2020 We found that rosiglitazone directly bound to the ligand binding domain (LBD) of RXRalpha and induced RXRalpha/LBD tetramerization. Rosiglitazone 14-27 retinoid X receptor alpha Homo sapiens 102-110 32828280-5 2020 Rosiglitazone inhibited the agonist-induced transcriptional activity of RXRalpha homodimers and heterodimers likely through inhibiting RXRalpha homo- and hetero-dimerization. Rosiglitazone 0-13 retinoid X receptor alpha Homo sapiens 72-80 32828280-5 2020 Rosiglitazone inhibited the agonist-induced transcriptional activity of RXRalpha homodimers and heterodimers likely through inhibiting RXRalpha homo- and hetero-dimerization. Rosiglitazone 0-13 retinoid X receptor alpha Homo sapiens 135-143 32828280-6 2020 In acute promyelocytic leukemia (APL) NB4 cells, rosiglitazone inhibited cell proliferation and induced cell differentiation, resulting from inhibiting RXRalpha/PML-RARalpha complex formation and down-regulating PML-RARalpha. Rosiglitazone 49-62 retinoid X receptor alpha Homo sapiens 152-160 32828280-7 2020 Together, our study identified RXRalpha as a novel target of rosiglitazone and RXRalpha mediating the anti-APL activity of rosiglitazone. Rosiglitazone 61-74 retinoid X receptor alpha Homo sapiens 31-39 32828280-7 2020 Together, our study identified RXRalpha as a novel target of rosiglitazone and RXRalpha mediating the anti-APL activity of rosiglitazone. Rosiglitazone 123-136 retinoid X receptor alpha Homo sapiens 31-39 32828280-7 2020 Together, our study identified RXRalpha as a novel target of rosiglitazone and RXRalpha mediating the anti-APL activity of rosiglitazone. Rosiglitazone 123-136 retinoid X receptor alpha Homo sapiens 79-87