Pub. Date : 2021 Feb
PMID : 32552008
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Previous studies showed that miR-129-5p had a low expression in GC, and homeobox gene C10 (HOXC10), a carcinogenic gene, was highly expressed in GC, while the molecular mechanism of miR-129-5p involved in apatinib resistance in GC cells is still unclear. | apatinib | microRNA 1295a | Homo sapiens |
| 2 | Previous studies showed that miR-129-5p had a low expression in GC, and homeobox gene C10 (HOXC10), a carcinogenic gene, was highly expressed in GC, while the molecular mechanism of miR-129-5p involved in apatinib resistance in GC cells is still unclear. | apatinib | microRNA 1295a | Homo sapiens |
| 3 | Results: MiR-129-5p had a low expression in GC tissues and apatinib-resistant cell lines, while HOXC10 was highly expressed. | apatinib | microRNA 1295a | Homo sapiens |
| 4 | The experiment in vivo also confirmed that miR-129-5p reduced apatinib resistance in GC cells by targetedly inhibiting HOXC10. | apatinib | microRNA 1295a | Homo sapiens |
| 5 | Conclusion: miR-129-5p restrains apatinib-resistant of GC cells by regulating HOXC10. | apatinib | microRNA 1295a | Homo sapiens |