Pub. Date : 2020 May 1
PMID : 32292063
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Peroxiredoxin 1 plays a primary role in protecting pancreatic ss-cells from hydrogen peroxide and peroxynitrite. | Hydrogen Peroxide | peroxiredoxin 1 | Rattus norvegicus |
| 2 | Peroxiredoxin 1 plays a primary role in protecting pancreatic ss-cells from hydrogen peroxide and peroxynitrite. | Peroxynitrous Acid | peroxiredoxin 1 | Rattus norvegicus |
| 3 | Here, using either glucose oxidase or menadione to continuously deliver hydrogen peroxide, or the combination of DPTA/NO and menadione to continuously deliver peroxynitrite, we tested the hypothesis that b-cells use peroxiredoxins to detoxify both of these reactive species. | Vitamin K 3 | peroxiredoxin 1 | Rattus norvegicus |
| 4 | Here, using either glucose oxidase or menadione to continuously deliver hydrogen peroxide, or the combination of DPTA/NO and menadione to continuously deliver peroxynitrite, we tested the hypothesis that b-cells use peroxiredoxins to detoxify both of these reactive species. | Peroxynitrous Acid | peroxiredoxin 1 | Rattus norvegicus |
| 5 | Either pharmacological inhibition with peroxiredoxin inhibitor conoidin A or specific depletion of cytoplasmic peroxiredoxin 1 (Prdx1) using siRNAs sensitizes INS 832/13 cells and rat islets to DNA damage and death induced by hydrogen peroxide or peroxynitrite. | Hydrogen Peroxide | peroxiredoxin 1 | Rattus norvegicus |
| 6 | Either pharmacological inhibition with peroxiredoxin inhibitor conoidin A or specific depletion of cytoplasmic peroxiredoxin 1 (Prdx1) using siRNAs sensitizes INS 832/13 cells and rat islets to DNA damage and death induced by hydrogen peroxide or peroxynitrite. | Hydrogen Peroxide | peroxiredoxin 1 | Rattus norvegicus |
| 7 | Either pharmacological inhibition with peroxiredoxin inhibitor conoidin A or specific depletion of cytoplasmic peroxiredoxin 1 (Prdx1) using siRNAs sensitizes INS 832/13 cells and rat islets to DNA damage and death induced by hydrogen peroxide or peroxynitrite. | Peroxynitrous Acid | peroxiredoxin 1 | Rattus norvegicus |
| 8 | Either pharmacological inhibition with peroxiredoxin inhibitor conoidin A or specific depletion of cytoplasmic peroxiredoxin 1 (Prdx1) using siRNAs sensitizes INS 832/13 cells and rat islets to DNA damage and death induced by hydrogen peroxide or peroxynitrite. | Peroxynitrous Acid | peroxiredoxin 1 | Rattus norvegicus |
| 9 | Together, these results suggest that ss-cells utilize cytoplasmic Prdx1 as a primary defense mechanism against both ROS and RNS. | ros | peroxiredoxin 1 | Rattus norvegicus |
| 10 | Together, these results suggest that ss-cells utilize cytoplasmic Prdx1 as a primary defense mechanism against both ROS and RNS. | Radon | peroxiredoxin 1 | Rattus norvegicus |