Title : β4-Nicotinic Receptors Are Critically Involved in Reward-Related Behaviors and Self-Regulation of Nicotine Reinforcement.

Pub. Date : 2020 Apr 22

PMID : 32184221






2 Functional Relationships(s)
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1 Human genome-wide association studies have linked polymorphisms in the CHRNA5-CHRNA3-CHRNB4 gene cluster, coding for the alpha5, alpha3 and beta4nAChR subunits, to nicotine addiction. Nicotine cholinergic receptor nicotinic beta 4 subunit Homo sapiens
2 These data indicate that beta4 is a critical modulator of reward-related behaviors.SIGNIFICANCE STATEMENT: Human genetic studies have provided strong evidence for a relationship between variants in the CHRNA5-CHRNA3-CHRNB4 gene cluster and nicotine addiction. Nicotine cholinergic receptor nicotinic beta 4 subunit Homo sapiens