PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32184221-0	2020	beta4-nicotinic receptors are critically involved in reward-related behaviors and self-regulation of nicotine reinforcement.	Nicotine	101-109	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	0-5	
32184221-2	2020	Human genome-wide association studies have linked polymorphisms in the CHRNA5-CHRNA3-CHRNB4 gene cluster, coding for the alpha5, alpha3 and beta4nAChR subunits, to nicotine addiction.	Nicotine	164-172	cholinergic receptor nicotinic alpha 5 subunit	Homo sapiens	71-77	
32184221-2	2020	Human genome-wide association studies have linked polymorphisms in the CHRNA5-CHRNA3-CHRNB4 gene cluster, coding for the alpha5, alpha3 and beta4nAChR subunits, to nicotine addiction.	Nicotine	164-172	cholinergic receptor nicotinic alpha 3 subunit	Homo sapiens	78-84	
32184221-2	2020	Human genome-wide association studies have linked polymorphisms in the CHRNA5-CHRNA3-CHRNB4 gene cluster, coding for the alpha5, alpha3 and beta4nAChR subunits, to nicotine addiction.	Nicotine	164-172	cholinergic receptor nicotinic beta 4 subunit	Homo sapiens	85-91	
32184221-3	2020	beta4*nAChRs have been implicated in nicotine withdrawal, aversion and reinforcement.	Nicotine	37-45	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	0-5	
32184221-4	2020	Here we show that beta4*nAChRs also are involved in non-nicotine-mediated responses that may predispose to addiction-related behaviors.	Nicotine	56-64	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	18-23	
32184221-8	2020	Conversely, at high nicotine doses, this was reversed and beta4KO self-administered more than WT mice while beta4 overexpressing mice avoided nicotine injections.	Nicotine	20-28	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	58-63	
32184221-9	2020	Viral expression of beta4 subunits in medial habenula (MHb), interpeduncular nucleus (IPN) and VTA of beta4KO mice revealed dose- and region-dependent differences: beta4*nAChRs in the VTA potentiated nicotine-mediated rewarding effects at all doses, whereas beta4*nAChRs in the MHb-IPN pathway, limited VTA-ICSA at high nicotine doses.	nachrs	170-176	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	20-25	
32184221-9	2020	Viral expression of beta4 subunits in medial habenula (MHb), interpeduncular nucleus (IPN) and VTA of beta4KO mice revealed dose- and region-dependent differences: beta4*nAChRs in the VTA potentiated nicotine-mediated rewarding effects at all doses, whereas beta4*nAChRs in the MHb-IPN pathway, limited VTA-ICSA at high nicotine doses.	nachrs	170-176	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	102-107	
32184221-9	2020	Viral expression of beta4 subunits in medial habenula (MHb), interpeduncular nucleus (IPN) and VTA of beta4KO mice revealed dose- and region-dependent differences: beta4*nAChRs in the VTA potentiated nicotine-mediated rewarding effects at all doses, whereas beta4*nAChRs in the MHb-IPN pathway, limited VTA-ICSA at high nicotine doses.	nachrs	170-176	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	102-107	
32184221-9	2020	Viral expression of beta4 subunits in medial habenula (MHb), interpeduncular nucleus (IPN) and VTA of beta4KO mice revealed dose- and region-dependent differences: beta4*nAChRs in the VTA potentiated nicotine-mediated rewarding effects at all doses, whereas beta4*nAChRs in the MHb-IPN pathway, limited VTA-ICSA at high nicotine doses.	Nicotine	200-208	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	20-25	
32184221-9	2020	Viral expression of beta4 subunits in medial habenula (MHb), interpeduncular nucleus (IPN) and VTA of beta4KO mice revealed dose- and region-dependent differences: beta4*nAChRs in the VTA potentiated nicotine-mediated rewarding effects at all doses, whereas beta4*nAChRs in the MHb-IPN pathway, limited VTA-ICSA at high nicotine doses.	nachrs	264-270	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	20-25	
32184221-9	2020	Viral expression of beta4 subunits in medial habenula (MHb), interpeduncular nucleus (IPN) and VTA of beta4KO mice revealed dose- and region-dependent differences: beta4*nAChRs in the VTA potentiated nicotine-mediated rewarding effects at all doses, whereas beta4*nAChRs in the MHb-IPN pathway, limited VTA-ICSA at high nicotine doses.	2-((3'-METHYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID	55-58	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	20-25	
32184221-9	2020	Viral expression of beta4 subunits in medial habenula (MHb), interpeduncular nucleus (IPN) and VTA of beta4KO mice revealed dose- and region-dependent differences: beta4*nAChRs in the VTA potentiated nicotine-mediated rewarding effects at all doses, whereas beta4*nAChRs in the MHb-IPN pathway, limited VTA-ICSA at high nicotine doses.	Nicotine	320-328	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	20-25	
32184221-10	2020	Together, our findings indicate that the lack of functional beta4*nAChRs result in deficits in reward sensitivity including increased ICSA at high doses of nicotine that is restored by re-expression of beta4*nAChRs in the MHb-IPN.	Nicotine	156-164	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	60-65	
32184221-10	2020	Together, our findings indicate that the lack of functional beta4*nAChRs result in deficits in reward sensitivity including increased ICSA at high doses of nicotine that is restored by re-expression of beta4*nAChRs in the MHb-IPN.	Nicotine	156-164	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	202-207	
32184221-10	2020	Together, our findings indicate that the lack of functional beta4*nAChRs result in deficits in reward sensitivity including increased ICSA at high doses of nicotine that is restored by re-expression of beta4*nAChRs in the MHb-IPN.	nachrs	66-72	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	60-65	
32184221-10	2020	Together, our findings indicate that the lack of functional beta4*nAChRs result in deficits in reward sensitivity including increased ICSA at high doses of nicotine that is restored by re-expression of beta4*nAChRs in the MHb-IPN.	nachrs	66-72	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	202-207	
32184221-10	2020	Together, our findings indicate that the lack of functional beta4*nAChRs result in deficits in reward sensitivity including increased ICSA at high doses of nicotine that is restored by re-expression of beta4*nAChRs in the MHb-IPN.	mhb-ipn	222-229	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	60-65	
32184221-10	2020	Together, our findings indicate that the lack of functional beta4*nAChRs result in deficits in reward sensitivity including increased ICSA at high doses of nicotine that is restored by re-expression of beta4*nAChRs in the MHb-IPN.	mhb-ipn	222-229	ATPase, H+ transporting, lysosomal V0 subunit A4	Mus musculus	202-207	
32184221-11	2020	These data indicate that beta4 is a critical modulator of reward-related behaviors.SIGNIFICANCE STATEMENT: Human genetic studies have provided strong evidence for a relationship between variants in the CHRNA5-CHRNA3-CHRNB4 gene cluster and nicotine addiction.	Nicotine	240-248	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	25-30	
32184221-11	2020	These data indicate that beta4 is a critical modulator of reward-related behaviors.SIGNIFICANCE STATEMENT: Human genetic studies have provided strong evidence for a relationship between variants in the CHRNA5-CHRNA3-CHRNB4 gene cluster and nicotine addiction.	Nicotine	240-248	cholinergic receptor nicotinic alpha 5 subunit	Homo sapiens	202-208	
32184221-11	2020	These data indicate that beta4 is a critical modulator of reward-related behaviors.SIGNIFICANCE STATEMENT: Human genetic studies have provided strong evidence for a relationship between variants in the CHRNA5-CHRNA3-CHRNB4 gene cluster and nicotine addiction.	Nicotine	240-248	cholinergic receptor nicotinic alpha 3 subunit	Homo sapiens	209-215	
32184221-11	2020	These data indicate that beta4 is a critical modulator of reward-related behaviors.SIGNIFICANCE STATEMENT: Human genetic studies have provided strong evidence for a relationship between variants in the CHRNA5-CHRNA3-CHRNB4 gene cluster and nicotine addiction.	Nicotine	240-248	cholinergic receptor nicotinic beta 4 subunit	Homo sapiens	216-222	
32184221-14	2020	Deletion of the beta4 subunit gene resulted in an addiction-related phenotype characterized by low anxiety, high novelty-induced response, lack of sensitivity to palatable food rewards and increased intracranial nicotine self-administration at high doses.	Nicotine	212-220	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	16-21	
32184221-15	2020	Lentiviral vector-induced re-expression of the beta4 subunit into either the MHb or IPN restored a "stop" signal on nicotine self-administration.	2-((3'-METHYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID	77-80	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	47-52	
32184221-15	2020	Lentiviral vector-induced re-expression of the beta4 subunit into either the MHb or IPN restored a "stop" signal on nicotine self-administration.	Nicotine	116-124	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	47-52