Title : Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine.

Pub. Date : 2020 May

PMID : 32156684






9 Functional Relationships(s)
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1 Flavin-Containing Monooxygenase 1 (FMO1) Catalyzes the Production of Taurine from Hypotaurine. hypotaurine flavin containing dimethylaniline monoxygenase 1 Homo sapiens
2 Flavin-Containing Monooxygenase 1 (FMO1) Catalyzes the Production of Taurine from Hypotaurine. hypotaurine flavin containing dimethylaniline monoxygenase 1 Homo sapiens
3 Here we show, both in vivo and in vitro, that the enzyme that oxygenates hypotaurine to produce taurine is flavin-containing monooxygenase 1 (FMO1). hypotaurine flavin containing dimethylaniline monoxygenase 1 Homo sapiens
4 Here we show, both in vivo and in vitro, that the enzyme that oxygenates hypotaurine to produce taurine is flavin-containing monooxygenase 1 (FMO1). hypotaurine flavin containing dimethylaniline monoxygenase 1 Homo sapiens
5 Metabolite analysis of the urine of Fmo1-null mice by 1H NMR spectroscopy revealed a build-up of hypotaurine and a deficit of taurine in comparison with the concentrations of these compounds in the urine of wild-type mice. hypotaurine flavin containing monooxygenase 1 Mus musculus
6 In vitro assays confirmed that human FMO1 catalyzes the conversion of hypotaurine to taurine utilizing either NADPH or NADH as co-factor. hypotaurine flavin containing dimethylaniline monoxygenase 1 Homo sapiens
7 The identification that the endogenous molecule hypotaurine is a substrate for the FMO1-catalyzed production of taurine resolves a long-standing mystery. hypotaurine flavin containing dimethylaniline monoxygenase 1 Homo sapiens
8 Here we show, both in vivo and in vitro, that flavin-containing monooxygenase 1 (FMO1) catalyzes the oxygenation of hypotaurine to produce taurine. hypotaurine flavin containing dimethylaniline monoxygenase 1 Homo sapiens
9 Here we show, both in vivo and in vitro, that flavin-containing monooxygenase 1 (FMO1) catalyzes the oxygenation of hypotaurine to produce taurine. hypotaurine flavin containing dimethylaniline monoxygenase 1 Homo sapiens