Title : Short-term supplementation of celecoxib-shifted butyrate production on a simulated model of the gut microbial ecosystem and ameliorated in vitro inflammation.

Pub. Date : 2020 Feb 19

PMID : 32075981






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Celecoxib has been effective in the prevention and treatment of chronic inflammatory disorders through inhibition of altered cyclooxygenase-2 (COX-2) pathways. celecoxib prostaglandin-endoperoxide synthase 2 Homo sapiens
2 Celecoxib has been effective in the prevention and treatment of chronic inflammatory disorders through inhibition of altered cyclooxygenase-2 (COX-2) pathways. celecoxib prostaglandin-endoperoxide synthase 2 Homo sapiens
3 Celecoxib was responsible for only 5% of the variance in bacterial community composition but celecoxib-exposed microbiota preserved barrier function and decreased concentrations of IL-8 and CXCL16 in a donor-dependent manner in our two models simulating gut inflammatory milieu. celecoxib C-X-C motif chemokine ligand 8 Homo sapiens
4 Celecoxib was responsible for only 5% of the variance in bacterial community composition but celecoxib-exposed microbiota preserved barrier function and decreased concentrations of IL-8 and CXCL16 in a donor-dependent manner in our two models simulating gut inflammatory milieu. celecoxib C-X-C motif chemokine ligand 16 Homo sapiens
5 Our results suggest that celecoxib-microbiome-host interactions may not only elicit adaptations in community composition but also in microbiota functionality, and these may need to be considered for guaranteeing efficient COX-2 inhibition. celecoxib prostaglandin-endoperoxide synthase 2 Homo sapiens