Pub. Date : 2020 Apr 1
PMID : 31927052
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tributyltin and triphenyltin induce 11beta-hydroxysteroid dehydrogenase 2 expression and activity through activation of retinoid X receptor alpha. | tributyltin | retinoid X receptor alpha | Homo sapiens |
| 2 | Tributyltin and triphenyltin induce 11beta-hydroxysteroid dehydrogenase 2 expression and activity through activation of retinoid X receptor alpha. | triphenyltin | retinoid X receptor alpha | Homo sapiens |
| 3 | Inhibition/knock-down of retinoid X receptor alpha (RXRalpha) in JEG-3 cells reduced the effect of organotins on 11beta-HSD2 activity, mRNA and protein levels, revealing involvement of RXRalpha. | Organotin Compounds | retinoid X receptor alpha | Homo sapiens |
| 4 | Inhibition/knock-down of retinoid X receptor alpha (RXRalpha) in JEG-3 cells reduced the effect of organotins on 11beta-HSD2 activity, mRNA and protein levels, revealing involvement of RXRalpha. | Organotin Compounds | retinoid X receptor alpha | Homo sapiens |
| 5 | Induction of placental 11beta-HSD2 activity by TBT, TPT and other endocrine disrupting chemicals acting as RXRalpha agonists may affect placental barrier function by altering the expression of glucocorticoid-dependent genes and resulting in decreased availability of active glucocorticoids for the fetus, disturbing development and increasing the risk for metabolic and cardiovascular complications in later life. | tributyltin | retinoid X receptor alpha | Homo sapiens |