Title : Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally.

Pub. Date : 2020 Feb 28

PMID : 31911440






3 Functional Relationships(s)
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1 Three of the four sterol reductases in cholesterol production, 7-dehydrocholesterol reductase (DHCR7), 14-dehydrocholesterol reductase (DHCR14), and lamin-B receptor (LBR), share evolutionary ties with a high level of sequence homology and predicted structural homology. Cholesterol lamin B receptor Homo sapiens
2 DHCR14 and LBR uniquely share the same Delta-14 reductase activity in cholesterol biosynthesis, yet little is known about their post-translational regulation. Cholesterol lamin B receptor Homo sapiens
3 We found that DHCR14 and LBR undergo differential post-translational regulation, with DHCR14 being rapidly turned over, triggered by cholesterol and other sterol intermediates, whereas LBR remained stable. dhcr14 lamin B receptor Homo sapiens