Title : Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats.

Pub. Date : 2020 Mar 1

PMID : 31830479






2 Functional Relationships(s)
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1 Treatment with VRP also decreased the accentuated MMP-14/TIMP-2 levels in 2K1C. Verapamil matrix metallopeptidase 14 Rattus norvegicus
2 SIGNIFICANCE: Treatment with VRP decreases calpain-1 and MMP-2 activities and also reduces TGF-beta and MMP-14/TIMP-2 levels in the LV of hypertensive rats, thus contributing to ameliorate cardiac hypertrophy. Verapamil matrix metallopeptidase 14 Rattus norvegicus