Title : PPARα ligand, AVE8134, and cyclooxygenase inhibitor therapy synergistically suppress lung cancer growth and metastasis.

Pub. Date : 2019 Dec 2

PMID : 31791289






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The increased 11-HETE partly neutralized the benefits provided by the Cyp2c44-EETs system inhibited by PPARalpha ligands in tumour-bearing mice. Hydroxyeicosatetraenoic Acids cytochrome P450, family 2, subfamily c, polypeptide 23 Mus musculus
2 The increased 11-HETE partly neutralized the benefits provided by the Cyp2c44-EETs system inhibited by PPARalpha ligands in tumour-bearing mice. 5,6-epoxy-8,11,14-eicosatrienoic acid cytochrome P450, family 2, subfamily c, polypeptide 23 Mus musculus
3 AVE8134 treatment worsened the tumour phenotype in Cyp2c44 knockout mice, indicating that AVE8134 has contradictory effects on tumour growth. 2-methyl-6-(3-(2-phenyloxazol-4-ylmethoxy)propoxymethyl)benzoic acid cytochrome P450, family 2, subfamily c, polypeptide 23 Mus musculus