PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31791289-2	2019	Peroxisome proliferator-activated nuclear receptor alpha (PPARalpha), known as a key nuclear transcription factor involved in glucose and lipid metabolism, has been also implicated in endothelial proliferation and angiogenesis.	Glucose	126-133	peroxisome proliferator activated receptor alpha	Mus musculus	58-67	
31791289-3	2019	However, the effects and potential mechanisms of the novel PPARalpha ligand, AVE8134, on LC growth and progression remain unclear.	2-methyl-6-(3-(2-phenyloxazol-4-ylmethoxy)propoxymethyl)benzoic acid	77-84	peroxisome proliferator activated receptor alpha	Mus musculus	59-68	
31791289-10	2019	Eicosanoid profile analysis showed that all PPARalpha ligands reduced the production of AA-derived epoxyeicosatrienoic acids (EETs) and increased the hydroxyl product, 11-hydroxyeicosatetraenoic acids (11-HETE).	5,6-epoxy-8,11,14-eicosatrienoic acid	99-124	peroxisome proliferator activated receptor alpha	Mus musculus	44-53	
31791289-10	2019	Eicosanoid profile analysis showed that all PPARalpha ligands reduced the production of AA-derived epoxyeicosatrienoic acids (EETs) and increased the hydroxyl product, 11-hydroxyeicosatetraenoic acids (11-HETE).	5,6-epoxy-8,11,14-eicosatrienoic acid	126-130	peroxisome proliferator activated receptor alpha	Mus musculus	44-53	
31791289-10	2019	Eicosanoid profile analysis showed that all PPARalpha ligands reduced the production of AA-derived epoxyeicosatrienoic acids (EETs) and increased the hydroxyl product, 11-hydroxyeicosatetraenoic acids (11-HETE).	Hydroxyl Radical	150-158	peroxisome proliferator activated receptor alpha	Mus musculus	44-53	
31791289-10	2019	Eicosanoid profile analysis showed that all PPARalpha ligands reduced the production of AA-derived epoxyeicosatrienoic acids (EETs) and increased the hydroxyl product, 11-hydroxyeicosatetraenoic acids (11-HETE).	Hydroxyeicosatetraenoic Acids	168-200	peroxisome proliferator activated receptor alpha	Mus musculus	44-53	
31791289-10	2019	Eicosanoid profile analysis showed that all PPARalpha ligands reduced the production of AA-derived epoxyeicosatrienoic acids (EETs) and increased the hydroxyl product, 11-hydroxyeicosatetraenoic acids (11-HETE).	Hydroxyeicosatetraenoic Acids	202-209	peroxisome proliferator activated receptor alpha	Mus musculus	44-53	
31791289-12	2019	The increased 11-HETE partly neutralized the benefits provided by the Cyp2c44-EETs system inhibited by PPARalpha ligands in tumour-bearing mice.	Hydroxyeicosatetraenoic Acids	14-21	cytochrome P450, family 2, subfamily c, polypeptide 23	Mus musculus	70-77	
31791289-12	2019	The increased 11-HETE partly neutralized the benefits provided by the Cyp2c44-EETs system inhibited by PPARalpha ligands in tumour-bearing mice.	Hydroxyeicosatetraenoic Acids	14-21	peroxisome proliferator activated receptor alpha	Mus musculus	103-112	
31791289-12	2019	The increased 11-HETE partly neutralized the benefits provided by the Cyp2c44-EETs system inhibited by PPARalpha ligands in tumour-bearing mice.	5,6-epoxy-8,11,14-eicosatrienoic acid	78-82	cytochrome P450, family 2, subfamily c, polypeptide 23	Mus musculus	70-77	
31791289-12	2019	The increased 11-HETE partly neutralized the benefits provided by the Cyp2c44-EETs system inhibited by PPARalpha ligands in tumour-bearing mice.	5,6-epoxy-8,11,14-eicosatrienoic acid	78-82	peroxisome proliferator activated receptor alpha	Mus musculus	103-112	
31791289-13	2019	AVE8134 treatment worsened the tumour phenotype in Cyp2c44 knockout mice, indicating that AVE8134 has contradictory effects on tumour growth.	2-methyl-6-(3-(2-phenyloxazol-4-ylmethoxy)propoxymethyl)benzoic acid	0-7	cytochrome P450, family 2, subfamily c, polypeptide 23	Mus musculus	51-58	
31791289-15	2019	CONCLUSION: In this study, we found that the degrees of inhibition on LC growth and metastasis by PPARalpha ligands depended on their bidirectional regulation on EETs and 11-HETE.	5,6-epoxy-8,11,14-eicosatrienoic acid	162-166	peroxisome proliferator activated receptor alpha	Mus musculus	98-107	
31791289-15	2019	CONCLUSION: In this study, we found that the degrees of inhibition on LC growth and metastasis by PPARalpha ligands depended on their bidirectional regulation on EETs and 11-HETE.	Hydroxyeicosatetraenoic Acids	171-178	peroxisome proliferator activated receptor alpha	Mus musculus	98-107	
31791289-16	2019	Considering their safety and efficacy, the novel PPARalpha ligand, AVE8134, is a potentially ideal anti-angiogenesis drug for cancer treatment when jointly applied with the COX inhibitor indomethacin.	2-methyl-6-(3-(2-phenyloxazol-4-ylmethoxy)propoxymethyl)benzoic acid	67-74	peroxisome proliferator activated receptor alpha	Mus musculus	49-58	
31791289-16	2019	Considering their safety and efficacy, the novel PPARalpha ligand, AVE8134, is a potentially ideal anti-angiogenesis drug for cancer treatment when jointly applied with the COX inhibitor indomethacin.	Indomethacin	187-199	peroxisome proliferator activated receptor alpha	Mus musculus	49-58