PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31791289-2 2019 Peroxisome proliferator-activated nuclear receptor alpha (PPARalpha), known as a key nuclear transcription factor involved in glucose and lipid metabolism, has been also implicated in endothelial proliferation and angiogenesis. Glucose 126-133 peroxisome proliferator activated receptor alpha Mus musculus 58-67 31791289-3 2019 However, the effects and potential mechanisms of the novel PPARalpha ligand, AVE8134, on LC growth and progression remain unclear. 2-methyl-6-(3-(2-phenyloxazol-4-ylmethoxy)propoxymethyl)benzoic acid 77-84 peroxisome proliferator activated receptor alpha Mus musculus 59-68 31791289-10 2019 Eicosanoid profile analysis showed that all PPARalpha ligands reduced the production of AA-derived epoxyeicosatrienoic acids (EETs) and increased the hydroxyl product, 11-hydroxyeicosatetraenoic acids (11-HETE). 5,6-epoxy-8,11,14-eicosatrienoic acid 99-124 peroxisome proliferator activated receptor alpha Mus musculus 44-53 31791289-10 2019 Eicosanoid profile analysis showed that all PPARalpha ligands reduced the production of AA-derived epoxyeicosatrienoic acids (EETs) and increased the hydroxyl product, 11-hydroxyeicosatetraenoic acids (11-HETE). 5,6-epoxy-8,11,14-eicosatrienoic acid 126-130 peroxisome proliferator activated receptor alpha Mus musculus 44-53 31791289-10 2019 Eicosanoid profile analysis showed that all PPARalpha ligands reduced the production of AA-derived epoxyeicosatrienoic acids (EETs) and increased the hydroxyl product, 11-hydroxyeicosatetraenoic acids (11-HETE). Hydroxyl Radical 150-158 peroxisome proliferator activated receptor alpha Mus musculus 44-53 31791289-10 2019 Eicosanoid profile analysis showed that all PPARalpha ligands reduced the production of AA-derived epoxyeicosatrienoic acids (EETs) and increased the hydroxyl product, 11-hydroxyeicosatetraenoic acids (11-HETE). Hydroxyeicosatetraenoic Acids 168-200 peroxisome proliferator activated receptor alpha Mus musculus 44-53 31791289-10 2019 Eicosanoid profile analysis showed that all PPARalpha ligands reduced the production of AA-derived epoxyeicosatrienoic acids (EETs) and increased the hydroxyl product, 11-hydroxyeicosatetraenoic acids (11-HETE). Hydroxyeicosatetraenoic Acids 202-209 peroxisome proliferator activated receptor alpha Mus musculus 44-53 31791289-12 2019 The increased 11-HETE partly neutralized the benefits provided by the Cyp2c44-EETs system inhibited by PPARalpha ligands in tumour-bearing mice. Hydroxyeicosatetraenoic Acids 14-21 cytochrome P450, family 2, subfamily c, polypeptide 23 Mus musculus 70-77 31791289-12 2019 The increased 11-HETE partly neutralized the benefits provided by the Cyp2c44-EETs system inhibited by PPARalpha ligands in tumour-bearing mice. Hydroxyeicosatetraenoic Acids 14-21 peroxisome proliferator activated receptor alpha Mus musculus 103-112 31791289-12 2019 The increased 11-HETE partly neutralized the benefits provided by the Cyp2c44-EETs system inhibited by PPARalpha ligands in tumour-bearing mice. 5,6-epoxy-8,11,14-eicosatrienoic acid 78-82 cytochrome P450, family 2, subfamily c, polypeptide 23 Mus musculus 70-77 31791289-12 2019 The increased 11-HETE partly neutralized the benefits provided by the Cyp2c44-EETs system inhibited by PPARalpha ligands in tumour-bearing mice. 5,6-epoxy-8,11,14-eicosatrienoic acid 78-82 peroxisome proliferator activated receptor alpha Mus musculus 103-112 31791289-13 2019 AVE8134 treatment worsened the tumour phenotype in Cyp2c44 knockout mice, indicating that AVE8134 has contradictory effects on tumour growth. 2-methyl-6-(3-(2-phenyloxazol-4-ylmethoxy)propoxymethyl)benzoic acid 0-7 cytochrome P450, family 2, subfamily c, polypeptide 23 Mus musculus 51-58 31791289-15 2019 CONCLUSION: In this study, we found that the degrees of inhibition on LC growth and metastasis by PPARalpha ligands depended on their bidirectional regulation on EETs and 11-HETE. 5,6-epoxy-8,11,14-eicosatrienoic acid 162-166 peroxisome proliferator activated receptor alpha Mus musculus 98-107 31791289-15 2019 CONCLUSION: In this study, we found that the degrees of inhibition on LC growth and metastasis by PPARalpha ligands depended on their bidirectional regulation on EETs and 11-HETE. Hydroxyeicosatetraenoic Acids 171-178 peroxisome proliferator activated receptor alpha Mus musculus 98-107 31791289-16 2019 Considering their safety and efficacy, the novel PPARalpha ligand, AVE8134, is a potentially ideal anti-angiogenesis drug for cancer treatment when jointly applied with the COX inhibitor indomethacin. 2-methyl-6-(3-(2-phenyloxazol-4-ylmethoxy)propoxymethyl)benzoic acid 67-74 peroxisome proliferator activated receptor alpha Mus musculus 49-58 31791289-16 2019 Considering their safety and efficacy, the novel PPARalpha ligand, AVE8134, is a potentially ideal anti-angiogenesis drug for cancer treatment when jointly applied with the COX inhibitor indomethacin. Indomethacin 187-199 peroxisome proliferator activated receptor alpha Mus musculus 49-58