Pub. Date : 2019 Nov 19
PMID : 31752398
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Postmortem tissue analysis reveals that hM4D-CNO animals had reduced Fos immunoreactivity in the dorsal striatum compared to rM3D-CNO animals and DREADD naive-CNO animals. | clozapine N-oxide | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | Cellular mechanisms in the dorsal striatum in hM4D-CNO animals reveal enhanced expression of D1R and Ca2+/calmodulin-dependent kinase II (CaMKII). | clozapine N-oxide | calcium/calmodulin dependent protein kinase II gamma | Homo sapiens |
| 3 | Conversely, rM3D-CNO animals had enhanced activity of extracellular signal-regulated kinase (Erk1/2) and Akt in the dorsal striatum, supporting rM3D-CNO interaction in these animals compared with drug naive controls, DREADD naive-CNO and hM4D-CNO animals. | clozapine N-oxide | mitogen-activated protein kinase 3 | Homo sapiens |
| 4 | Conversely, rM3D-CNO animals had enhanced activity of extracellular signal-regulated kinase (Erk1/2) and Akt in the dorsal striatum, supporting rM3D-CNO interaction in these animals compared with drug naive controls, DREADD naive-CNO and hM4D-CNO animals. | clozapine N-oxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Conversely, rM3D-CNO animals had enhanced activity of extracellular signal-regulated kinase (Erk1/2) and Akt in the dorsal striatum, supporting rM3D-CNO interaction in these animals compared with drug naive controls, DREADD naive-CNO and hM4D-CNO animals. | clozapine N-oxide | mitogen-activated protein kinase 3 | Homo sapiens |
| 6 | Conversely, rM3D-CNO animals had enhanced activity of extracellular signal-regulated kinase (Erk1/2) and Akt in the dorsal striatum, supporting rM3D-CNO interaction in these animals compared with drug naive controls, DREADD naive-CNO and hM4D-CNO animals. | clozapine N-oxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 7 | Conversely, rM3D-CNO animals had enhanced activity of extracellular signal-regulated kinase (Erk1/2) and Akt in the dorsal striatum, supporting rM3D-CNO interaction in these animals compared with drug naive controls, DREADD naive-CNO and hM4D-CNO animals. | clozapine N-oxide | mitogen-activated protein kinase 3 | Homo sapiens |
| 8 | Conversely, rM3D-CNO animals had enhanced activity of extracellular signal-regulated kinase (Erk1/2) and Akt in the dorsal striatum, supporting rM3D-CNO interaction in these animals compared with drug naive controls, DREADD naive-CNO and hM4D-CNO animals. | clozapine N-oxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 9 | Conversely, rM3D-CNO animals had enhanced activity of extracellular signal-regulated kinase (Erk1/2) and Akt in the dorsal striatum, supporting rM3D-CNO interaction in these animals compared with drug naive controls, DREADD naive-CNO and hM4D-CNO animals. | clozapine N-oxide | mitogen-activated protein kinase 3 | Homo sapiens |
| 10 | Conversely, rM3D-CNO animals had enhanced activity of extracellular signal-regulated kinase (Erk1/2) and Akt in the dorsal striatum, supporting rM3D-CNO interaction in these animals compared with drug naive controls, DREADD naive-CNO and hM4D-CNO animals. | clozapine N-oxide | AKT serine/threonine kinase 1 | Homo sapiens |