Pub. Date : 2019
PMID : 31664305
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Upregulation of miR-129-5p increases the sensitivity to Taxol through inhibiting HMGB1-mediated cell autophagy in breast cancer MCF-7 cells. | Paclitaxel | microRNA 1295a | Homo sapiens |
| 2 | In this study, we aimed to explore the role of miR-129-5p in regulating the sensitivity of breast cancer cells to Taxol. | Paclitaxel | microRNA 1295a | Homo sapiens |
| 3 | Furthermore, miR-129-5p overexpression increased the sensitivity of MCF-7 cells to Taxol. | Paclitaxel | microRNA 1295a | Homo sapiens |
| 4 | Taken together, our findings suggested that miR-129-5p increased the chemosensitivity of MCF-7 cells to Taxol through suppressing autophagy and enhancing apoptosis by inhibiting HMGB1. | Paclitaxel | microRNA 1295a | Homo sapiens |
| 5 | Using miR-129-5p/HMGB1/autophagy-based therapeutic strategies may be a potential treatment for overcoming Taxol resistance in breast cancer. | Paclitaxel | microRNA 1295a | Homo sapiens |