Title : Epithelial Alarmins in Serum and Exhaled Breath in Patients with Idiopathic Pulmonary Fibrosis: A Prospective One-Year Follow-Up Cohort Study.

Pub. Date : 2019 Oct 2

PMID : 31581688






3 Functional Relationships(s)
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1 Prospective analysis of changes in the epithelial alarmin levels showed significantly decreased IL-25 and TSLP EBC concentrations after 12 months of antifibrotic treatment (p < 0.05), which was observed in the subgroup of IPF patients treated with pirfenidone, but not in those treated with nintedanib. pirfenidone interleukin 25 Homo sapiens
2 In stable patients with IPF over a study period (absolute forced vital capacity (FVC) % of predicted decline/year <= 5%, n = 25), a significant decrease in the EBC levels of both IL-25 and TSLP after 12 months of antifibrotic treatment was noted (p < 0.05), whereas, in progressor IPF patients (absolute FVC % of predicted decline/year > 5%, n = 10), a significant decrease was noted in the IL-25 EBC levels only (p < 0.05). NSC638702 interleukin 25 Homo sapiens
3 In stable patients with IPF over a study period (absolute forced vital capacity (FVC) % of predicted decline/year <= 5%, n = 25), a significant decrease in the EBC levels of both IL-25 and TSLP after 12 months of antifibrotic treatment was noted (p < 0.05), whereas, in progressor IPF patients (absolute FVC % of predicted decline/year > 5%, n = 10), a significant decrease was noted in the IL-25 EBC levels only (p < 0.05). NSC638702 interleukin 25 Homo sapiens