Pub. Date : 2019 Sep 5
PMID : 31484833
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program. | Vincristine | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 2 | Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program. | Bortezomib | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 3 | We showed previously that genetic deletion of SARM1 blocks vincristine-induced neuropathy and demonstrate here that it also prevents axon destruction following administration of bortezomib in vitro and in vivo. | Vincristine | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 4 | We showed previously that genetic deletion of SARM1 blocks vincristine-induced neuropathy and demonstrate here that it also prevents axon destruction following administration of bortezomib in vitro and in vivo. | Bortezomib | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 5 | Using cultured neurons, we found that vincristine and bortezomib converge on a core axon degeneration program consisting of nicotinamide mononucleotide NMNAT2, SARM1, and loss of NAD+ but engage different upstream mechanisms that closely resemble Wallerian degeneration after vincristine and apoptosis after bortezomib. | Vincristine | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 6 | Using cultured neurons, we found that vincristine and bortezomib converge on a core axon degeneration program consisting of nicotinamide mononucleotide NMNAT2, SARM1, and loss of NAD+ but engage different upstream mechanisms that closely resemble Wallerian degeneration after vincristine and apoptosis after bortezomib. | Bortezomib | sterile alpha and TIR motif containing 1 | Homo sapiens |