Pub. Date : 2019 Aug 29
PMID : 31464590
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: THK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target bindings have been reported. | THK5351 | microtubule associated protein tau | Homo sapiens |
| 2 | Recent data support the hypothesis that THK5351 binds to monoamine oxidase B (MAO-B) expressed from reactive astrocytes and that flortaucipir has an affinity toward MAO-A and B; however, pathological evidence is lacking. | THK5351 | monoamine oxidase B | Homo sapiens |
| 3 | Recent data support the hypothesis that THK5351 binds to monoamine oxidase B (MAO-B) expressed from reactive astrocytes and that flortaucipir has an affinity toward MAO-A and B; however, pathological evidence is lacking. | THK5351 | monoamine oxidase B | Homo sapiens |
| 4 | CONCLUSIONS: Our findings add pathological evidence that increased THK5351 uptake in sporadic CJD patients might be caused by an off-target binding driven by its high affinity for MAO-B. | THK5351 | monoamine oxidase B | Homo sapiens |