Pub. Date : 2019 Aug 27
PMID : 31455656
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production. | Reactive Oxygen Species | bone marrow stromal cell antigen 1 | Homo sapiens |
| 2 | CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production. | Reactive Oxygen Species | bone marrow stromal cell antigen 1 | Homo sapiens |
| 3 | In vitro experiments show that the bactericidal ability was compromised in Cd157 knockout (KO) macrophages, which was due to impaired M. tuberculosis-induced reactive oxygen species (ROS) production. | Reactive Oxygen Species | bone marrow stromal cell antigen 1 | Homo sapiens |
| 4 | In vitro experiments show that the bactericidal ability was compromised in Cd157 knockout (KO) macrophages, which was due to impaired M. tuberculosis-induced reactive oxygen species (ROS) production. | Reactive Oxygen Species | bone marrow stromal cell antigen 1 | Homo sapiens |
| 5 | We further reveal that CD157 interacts with TLR2 and PKCzeta and facilitates M. tuberculosis-induced ROS production in Cd157 KO macrophages, which resulted in enhanced M. tuberculosis killing. | Reactive Oxygen Species | bone marrow stromal cell antigen 1 | Homo sapiens |
| 6 | We further reveal that CD157 interacts with TLR2 and PKCzeta and facilitates M. tuberculosis-induced ROS production in Cd157 KO macrophages, which resulted in enhanced M. tuberculosis killing. | Reactive Oxygen Species | bone marrow stromal cell antigen 1 | Homo sapiens |
| 7 | In conclusion, we have identified a novel protective immune function of CD157 during M. tuberculosis infection via TLR2-dependent ROS production. | Reactive Oxygen Species | bone marrow stromal cell antigen 1 | Homo sapiens |