Pub. Date : 2019 Sep 15
PMID : 31323261
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Protective effect of sestrin2 against iron overload and ferroptosis-induced liver injury. | Iron | sestrin 2 | Mus musculus |
| 2 | In the current study, we investigated whether ferroptosis inducing compounds including erastin, sorafenib, and buthionine sulfoximine affect Sesn2 expression and the role of Sesn2 in cytoprotection against ferroptosis-mediated cell death. | erastin | sestrin 2 | Mus musculus |
| 3 | In the current study, we investigated whether ferroptosis inducing compounds including erastin, sorafenib, and buthionine sulfoximine affect Sesn2 expression and the role of Sesn2 in cytoprotection against ferroptosis-mediated cell death. | Sorafenib | sestrin 2 | Mus musculus |
| 4 | In the current study, we investigated whether ferroptosis inducing compounds including erastin, sorafenib, and buthionine sulfoximine affect Sesn2 expression and the role of Sesn2 in cytoprotection against ferroptosis-mediated cell death. | Buthionine Sulfoximine | sestrin 2 | Mus musculus |
| 5 | Treatment with erastin upregulated Sesn2 mRNA levels and luciferase reporter gene activity, and erastin-mediated Sesn2 induction was transcriptionally regulated by NF-E2-related factor 2 (Nrf2). | erastin | sestrin 2 | Mus musculus |
| 6 | Furthermore, deletion of the antioxidant response element (ARE) in the Sesn2 promoter or Nrf2 knockout or knockdown abolished erastin-induced Sesn2 expression. | erastin | sestrin 2 | Mus musculus |
| 7 | Furthermore, deletion of the antioxidant response element (ARE) in the Sesn2 promoter or Nrf2 knockout or knockdown abolished erastin-induced Sesn2 expression. | erastin | sestrin 2 | Mus musculus |
| 8 | In cells expressing Sesn2, erastin-induced cell death, ROS formation, and glutathione depletion were almost completely inhibited compared to that in control cells. | Reactive Oxygen Species | sestrin 2 | Mus musculus |
| 9 | In cells expressing Sesn2, erastin-induced cell death, ROS formation, and glutathione depletion were almost completely inhibited compared to that in control cells. | Glutathione | sestrin 2 | Mus musculus |
| 10 | Treatment with phenylhydrazine in mice, well-reported iron overload liver injury model, increased ALT and AST levels and altered histological features, which were almost completely inhibited by adenoviral Sesn2 infection. | phenylhydrazine | sestrin 2 | Mus musculus |
| 11 | Treatment with phenylhydrazine in mice, well-reported iron overload liver injury model, increased ALT and AST levels and altered histological features, which were almost completely inhibited by adenoviral Sesn2 infection. | Iron | sestrin 2 | Mus musculus |
| 12 | Collectively, our results suggest that ferroptosis-mediated Sesn2 induction is dependent on Nrf2 and plays a protective role against iron overload and ferroptosis-induced liver injury. | Iron | sestrin 2 | Mus musculus |