Pub. Date : 2019 Jun 24
PMID : 31164445
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lag1 and Lac1 lie in an enzymatic branch point of the sphingolipid pathway that is interconnected by the activity of the C4 hydroxylase, Sur2. | Sphingolipids | sphingosine N-acyltransferase LAG1 | Saccharomyces cerevisiae S288C |
| 2 | By uncoupling the enzymatic branch point and using lipidomic mass spectrometry, metabolic labeling and in vitro assays we show that Lag1 preferentially synthesizes phyto-sphingolipids. | phyto-sphingolipids | sphingosine N-acyltransferase LAG1 | Saccharomyces cerevisiae S288C |
| 3 | Using photo-bleaching experiments we show that Lag1 is uniquely required for the establishment of a lateral diffusion barrier in the nuclear envelope, which depends on phytoceramide. | phytoceramide | sphingosine N-acyltransferase LAG1 | Saccharomyces cerevisiae S288C |