Pub. Date : 2019 May 31
PMID : 31128467
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death. | Cyclic ADP-Ribose | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 2 | SARM1, an NAD-utilizing enzyme, regulates axonal degeneration. | NAD | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 3 | We show that CZ-48, a cell-permeant mimetic of NMN, activated SARM1 in vitro and in cellulo to cyclize NAD and produce a Ca2+ messenger, cADPR, with similar efficiency as NMN. | Camptothecin-20-O-propionate | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 4 | We show that CZ-48, a cell-permeant mimetic of NMN, activated SARM1 in vitro and in cellulo to cyclize NAD and produce a Ca2+ messenger, cADPR, with similar efficiency as NMN. | NAD | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 5 | CZ-48 activated SARM1 via a conformational change of the auto-inhibitory domain and dimerization of its catalytic domain. | Camptothecin-20-O-propionate | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 6 | Both catalyzed similar set of reactions, but SARM1 had much higher NAD-cyclizing activity, making it more efficient in elevating cADPR. | NAD | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 7 | CZ-48 acted selectively, activating SARM1 but inhibiting CD38. | Camptothecin-20-O-propionate | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 8 | In SARM1-overexpressing cells, CZ-48 elevated cADPR, depleted NAD and ATP, and induced non-apoptotic death. | NAD | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 9 | In SARM1-overexpressing cells, CZ-48 elevated cADPR, depleted NAD and ATP, and induced non-apoptotic death. | Adenosine Triphosphate | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 10 | CZ-48 is a specific modulator of SARM1 functions in cells. | Camptothecin-20-O-propionate | sterile alpha and TIR motif containing 1 | Homo sapiens |