Title : Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the β1-adrenoceptor-mediated inotropic response.

Pub. Date : 2019 Jun

PMID : 31009605






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PDE4 inhibition increased noradrenaline potency in wild type and AC5 KO, but not AC6 KO. Norepinephrine adenylate cyclase 5 Mus musculus
2 PDE3 inhibition increased noradrenaline potency only in AC5 KO that was treated prior with PTX. Norepinephrine adenylate cyclase 5 Mus musculus